AICAR Acadesine 99%HPLC AMPK 阻害剤
It is not approved by the Food and Drug Administration (FDA) for use in humans. The FDA has also clarified that it is one among many peptides or drugs that are unlawful to use in making compounded medications2. This means that compounding pharmacies (special pharmacies that can custom mix medications) are not supposed to make medications with MOTS-c. AICAR has been shown to steroids improve endurance and exercise stamina in a rat skeletal muscle study. AICARis a naturally occurring molecule that acts as an intermediate in the synthesis of other nucleosides.
AMPKシグナル伝達経路
Our team’s expertise and rigorous standards ensure that each product meets the highest level of purity and effectiveness. Our products are verified by independent third party laboratories to meet quality standards. All of the products are to be handled only by properly trained and qualified LABORATORY or RESEARCH professionals. Experienced athletes can gradually increase the dosage up to 100 mg per day for optimal results.
In addition, AICAr is still a highly promising pharmacological agent having many beneficial effects in metabolism, hypoxia, exercise, and cancer. In human aortic endothelial cells, AICAr stimulated AMPK activity and nitric oxide (NO) production, and the effects were proved to be AMPK-dependent since the effects were inhibited by the expression of a dominant-negative (DN) AMPK mutant 60. Similar AMPK-dependent effects on NO production were observed in response to hypoxia 61, and studies performed in the knockout of the upstream kinase LKB1 confirmed the important role of AMPK in angiogenesis 62.
- It is a promising substance for study into metabolic diseases, weight management, and future therapeutic uses due to these actions.
- The antifolate pemetrexed inhibits the folate-dependent enzyme in de novo purine biosynthesis, increases ZMP, and activates AMPK 106.
- One study found that AICAR inhibited the growth of cancerous cells in prostate tissues.
- With its unique properties, including the regulation of glucose metabolism, improvement of muscle function, and stimulation of energy processes at the cellular level, Aicar offers numerous potential benefits.
Potential Clinical Applications of AICAR Norway
AICAR has been found to possess anti-cancer properties, inhibiting the growth of cancer cells both in vitro and in vivo. This effect is primarily mediated through AMPK activation, which leads to the inhibition of the mTOR pathway—a key regulator of cell growth and proliferation. By suppressing mTOR signaling, AICAR induces cell cycle arrest and apoptosis in cancer cells, thereby reducing tumor growth. Research indicates that AICAR, being an activator of AMPK, might have the potential to treat obesity.
By influencing these pathways, AICAR promotes energy efficiency and supports cellular function during energy stress. However, due to its experimental nature, AICAR’s full effects and mechanisms are still under active research. No matter whether being AMPK-dependent or independent, metabolic effects of AICAr may be of relevance for the potential treatment of type 2 diabetes 41.
Some articles refer to AMPK activators as “exercise-in-a-pill” in the hope that using an AMPK activator will cause the same changes in the body as exercise. Research on AICAR will continue and, as it does, these ethical and regulatory landscapes will likely continue to transform. Hence researchers conducting studies that involve the use of AICAR must remain abreast of current regulations and ethical guidelines. As you research AICAR, it’s also important to buy it from reputable sources that comply with all relevant regulations. AICAR has not achieved medical approval for humans from major regulatory bodies (FDA, EMA) as of 2024.
